2MTT: Dicarba Analogues of alpha-Conotoxin RgIA

Non-reducible analogues of alpha-conotoxin RgIA: [3,12]-cis dicarba RgIA. Determined by solution NMR. Released 26 Nov 2014.

Method

Solution NMR

Organism

synthetic construct

Chains

1

Atoms

106

Mol. weight

1.54 kDa

Released

26 Nov 2014

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Molecules and chains

>2MTT_1 Dicarba Analogues of alpha-Conotoxin RgIA (chains A)
GCASDPRCRYRAR

Primary citation

Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets. Chhabra, S., Belgi, A., Bartels, P. et al. J Med Chem (2014) 57:9933-9944. DOI 10.1021/jm501126u · PubMed

Related structures

Other PDB entries of the same protein (UniProt P0C1D0 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 6HY7 2.26 Å, Crystal structure of alpha9 nAChR extracellular domain in complex with alpha-conotoxin…
• 7EGR 2.5 Å, Co-crystal structure of Ac-AChBPP in complex with RgIA
• 2JUQ alpha-RgIA, a Novel Conotoxin that Blocks the alpha9-alpha10 nAChR
• 2JUR alpha RgIA, a Novel Conotoxin that Blocks the alpha9-alpha10 nAChR
• 2JUS alpha RgIA, a Novel Conotoxin that Blocks the alpha9-alpha10 nAChR
• 2JUT alpha RgIA, a Novel Conotoxin that Blocks the alpha9-alpha10 nAChR
• 2MTO Non-reducible analogues of alpha-conotoxin RgIA: [2,8]-cis dicarba RgIA
• 8W16 Pyroglutamaic acid position 1 synthetic analogue of RgIA
• 8W17 Lactam bridge synthetic analogue of RgIA

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