Replicase polyprotein 1ab (rep) is a 303-residue protein from Severe acute respiratory syndrome coronavirus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P0C6X7.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 95.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 93% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein
Interacts with host PHB and PHB2
Host cytoplasm, Host endosome, Host membrane, Host Golgi apparatus, Host cytoplasm, host perinuclear region, Host endoplasmic reticulum, Host endoplasmic reticulum-Golgi intermediate compartment
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2ACF | X-ray | 1.4 Å | A/B/C/D=1002-1176 |
| 6W79 | X-ray | 1.46 Å | A=3241-3546 |
| 6WCO | X-ray | 1.48 Å | A=3241-3546 |
| 5C5O | X-ray | 1.5 Å | A/B=3241-3546 |
| 8CB3 | X-ray | 1.57 Å | A/B/C=1000-1173 |
| 2H2Z | X-ray | 1.6 Å | A=3241-3546 |
| 4TWY | X-ray | 1.6 Å | A=3241-3546 |
| 5N19 | X-ray | 1.62 Å | A=3241-3546 |
| 5C5N | X-ray | 1.69 Å | A=3241-3546 |
| 2DUC | X-ray | 1.7 Å | A/B=3241-3546 |
| 2QCY | X-ray | 1.75 Å | A=3241-3546 |
| 2Z94 | X-ray | 1.78 Å | A=3241-3546 |
| 2Z3C | X-ray | 1.79 Å | A=3241-3546 |
| 2FAV | X-ray | 1.8 Å | A/B/C=1000-1173 |
| 2FYG | X-ray | 1.8 Å | A=4240-4362 |
| 2OP9 | X-ray | 1.8 Å | A/B=3241-3541 |
| 2GT7 | X-ray | 1.82 Å | A/B=3241-3546 |
| 2AMD | X-ray | 1.85 Å | A/B=3241-3546 |
| 2FE8 | X-ray | 1.85 Å | A/B/C=1541-1854 |
| 2Z9K | X-ray | 1.85 Å | A/B=3241-3546 |
Showing 20 of 104 experimental structures (best resolution first).
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