Mambalgin-1 is a 78-residue protein from Dendroaspis polylepis polylepis. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0DKR6.
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The mean pLDDT of this model is 89.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 47% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
This three-finger toxin inhibits ASIC channels. It acts as a gating modifier toxin by decreasing the apparent proton sensitivity of activation and by slightly increasing the apparent proton sensitivity for inactivation (PubMed:23034652). It binds more tightly to the closed state and to a much lesser extent the inactivated/desensitized state of ASIC1a isoform of ASIC1 (PubMed:23034652). It interacts directly with the outside surface of the thumb domain of chicken ASIC1a (ASIC1a), but does not insert into the acidic pocket as suggested for mambalgin-2 (PubMed:29872539). This binding leads to relocation of the thumb domain that could disrupt the acidic pocket of cASIC1a (PubMed:29872539). It…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5DO6 | X-ray | 1.7 Å | A/B=22-78 |
| 5DU1 | X-ray | 1.8 Å | A/B/C/D=22-78 |
| 5DZ5 | X-ray | 1.95 Å | A/B=22-78 |
| 7ULB | X-ray | 2.49 Å | A/B/C/D=22-78 |
| 7CFT | EM | 3.9 Å | D/E/F=22-78 |
| 2MJY | NMR | A=22-78 |
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