Middle T antigen is a 421-residue protein from Murine polyomavirus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P0DOJ7.
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The mean pLDDT of this model is 64.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 39% |
What pLDDT means and how to read it
Plays a role in transformation by modulating the activities of cellular proteins involved in control of cell proliferation and by acting as a functional homolog of an activated tyrosine kinase-associated growth-factor receptor. Recruits upon association with host Ppp2/PP2A the Src tyrosine kinase components Src, Yes and Fyn, thereby activating their kinase activity. Activation of Shc1, Pclg1 and p85 mediate signal transduction pathways leading to cell cycle progression and cell division. MT also plays a role in regulation of early and late gene expression and in viral DNA replication
Interacts with host Ppp2/PP2A A and C subunits; this interaction alters Ppp2/PP2A substrate specificity and localization. Interacts with host Src, Yes1, and Fyn. Interacts with host Shc1, Plcg1 and p85; these interactions lead to cell cycle progression. Interacts with host 14-3-3 proteins
Host membrane
Compare the prediction with experimentally determined structures of the same protein:
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