Androgen receptor (AR) is a 920-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P10275.
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The mean pLDDT of this model is 57.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 27% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 58% |
What pLDDT means and how to read it
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3
Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7. Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PQBP1, RANBP9, RBAK, SPDEF, SRA1, TGFB1I1 and RREB1. Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8E1A | X-ray | 1.2 Å | A=665-920 |
| 7ZTZ | X-ray | 1.4 Å | A=672-920 |
| 4OHA | X-ray | 1.42 Å | A=671-920 |
| 5V8Q | X-ray | 1.44 Å | A=672-920 |
| 2AX6 | X-ray | 1.5 Å | A=665-920 |
| 3L3X | X-ray | 1.55 Å | A=671-919 |
| 8FH0 | X-ray | 1.59 Å | A=663-920 |
| 8FH2 | X-ray | 1.59 Å | A=663-920 |
| 8FGZ | X-ray | 1.61 Å | A=663-920 |
| 2AM9 | X-ray | 1.64 Å | A=655-920 |
| 2AX9 | X-ray | 1.65 Å | A=665-920 |
| 2PNU | X-ray | 1.65 Å | A=655-920 |
| 3B66 | X-ray | 1.65 Å | A=672-920 |
| 1T65 | X-ray | 1.66 Å | A=670-920 |
| 7ZU1 | X-ray | 1.68 Å | A=672-920 |
| 8FH1 | X-ray | 1.69 Å | A=663-920 |
| 2AX8 | X-ray | 1.7 Å | A=665-920 |
| 3RLL | X-ray | 1.7 Å | A=672-918 |
| 3V49 | X-ray | 1.7 Å | A=655-920, B=21-31 |
| 7ZU2 | X-ray | 1.74 Å | A=672-920 |
Showing 20 of 95 experimental structures (best resolution first).
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