Retinoic acid receptor alpha (RARA) is a 462-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P10276.
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The mean pLDDT of this model is 78.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Receptor for retinoic acid (PubMed:16417524, PubMed:19850744, PubMed:20215566, PubMed:21152046, PubMed:37478846). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:21152046, PubMed:28167758, PubMed:37478846). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580, PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone…
Heterodimer; with RXRA (via C-terminus); association with RXRA is enhanced by pulsatile shear stress (PubMed:10698945, PubMed:10882070, PubMed:15509776, PubMed:20215566, PubMed:21152046, PubMed:28167758). Binds DNA preferentially as a heterodimer (PubMed:10698945, PubMed:28167758). RXRA serves as enhancer to induce RARA binding to RARE (PubMed:30468856). Interacts with RXRG (PubMed:28167758).…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9GFE | X-ray | 1.58 Å | A=181-415 |
| 1DSZ | X-ray | 1.7 Å | A=82-167 |
| 3KMR | X-ray | 1.8 Å | A=176-421 |
| 5K13 | X-ray | 1.85 Å | A=181-426 |
| 7WQQ | X-ray | 1.9 Å | A=176-421 |
| 3KMZ | X-ray | 2.1 Å | A/B=176-421 |
| 9GFI | X-ray | 2.1 Å | A=180-415 |
| 6XWG | X-ray | 2.4 Å | D=82-167 |
| 7APO | X-ray | 2.4 Å | A/B=176-421 |
| 1DKF | X-ray | 2.5 Å | B=182-416 |
| 7AOS | X-ray | 2.55 Å | B=176-421 |
| 3A9E | X-ray | 2.75 Å | B=153-421 |
| 4DQM | X-ray | 2.75 Å | A/C=182-415 |
| 7QAA | X-ray | 2.76 Å | B=182-416 |
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