HLA class I histocompatibility antigen, C alpha chain (HLA-C) is a 366-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P10321.
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The mean pLDDT of this model is 86.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 74% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity (PubMed:11172028, PubMed:20104487, PubMed:20439706, PubMed:20972337, PubMed:24091323, PubMed:28649982, PubMed:29312307). In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells (PubMed:16141329). In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary for placentation and…
Heterotrimer that consists of an alpha chain HLA-C, a beta chain B2M and a peptide (peptide-HLA-C-B2M) (PubMed:10850706, PubMed:24990997, PubMed:28649982). Early in biogenesis, HLA-C-B2M dimer interacts with the components of the peptide-loading complex composed of TAPBP, TAP1-TAP2, TAPBPL, PDIA3/ERP57 and CALR (PubMed:18420581). Interacts with TAP1-TAP2 transporter via TAPBP; this interaction…
Cell membrane, Endoplasmic reticulum membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6JTO | X-ray | 1.7 Å | A=26-298 |
| 5W6A | X-ray | 1.74 Å | A/C=25-300 |
| 4NT6 | X-ray | 1.84 Å | A=26-298 |
| 5W67 | X-ray | 2.3 Å | A=25-300 |
| 5VGD | X-ray | 2.32 Å | A=26-302 |
| 3BZF | X-ray | 2.5 Å | P/Q=3-11 |
| 6PAG | X-ray | 2.5 Å | A=25-302 |
| 5VGE | X-ray | 2.6 Å | A=26-300 |
| 1QQD | X-ray | 2.7 Å | A=26-298 |
| 1IM9 | X-ray | 2.8 Å | A/E=26-299 |
| 5W69 | X-ray | 2.8 Å | A/C/E/G=25-300 |
| 1EFX | X-ray | 3.0 Å | A=26-302 |
| 6PA1 | X-ray | 3.01 Å | A/E=25-301 |
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