Non-structural protein V (P/V) is a 222-residue protein from Parainfluenza virus 5. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P11207.
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The mean pLDDT of this model is 57.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 11% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 24% |
| Below 50 | Very low: often disordered regions | 44% |
What pLDDT means and how to read it
Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Efficiently blocks type I IFN signaling following infection by behaving as a substrate receptor for CUL4-DDB1 E3 ligase complex and targeting host STAT1 for proteasomal degradation. Blocks the type I interferon signaling pathway by disrupting the RIG-I signaling pathway (By similarity)
Interacts with host DDB1, STAT2 and IFIH1/MDA5. Interacts with host RIGI regulatory protein (via CARDs domain) and host TRIM25 (via SPRY domain); these interactions prevent TRIM25-mediated ubiquitination of RIG-I and disrupts downstream RIG-I signaling (PubMed:29321315)
Host cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4I1S | X-ray | 2.29 Å | B=168-219 |
| 2B5L | X-ray | 2.85 Å | C/D=1-222 |
| 2HYE | X-ray | 3.1 Å | B=1-222 |
| 2K48 | NMR | A=53-89 |
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