Guanine nucleotide-binding protein G(t) subunit alpha-1 (GNAT1) is a 350-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P11488.
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The mean pLDDT of this model is 94.2 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 87% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Alpha subunit of the heterotrimeric guanine nucleotide-binding protein (G protein) that transduces signals from the G protein-coupled photoreceptor rhodopsin (RHO). Essential for normal RHO-mediated light perception in retinal rod photoreceptors (PubMed:22190596). Functions as a GTPase, cycling between an active GTP-bound state and an inactive GDP-bound state. Under dim light conditions, photoactivated RHO promotes GDP release and GTP binding. In its active state, GNAT1 stimulates downstream effectors, including rod cGMP-phosphodiesterase (PDE6) complex, to mediate the phototransduction cascade (By similarity). Activation of the PDE6 complex occurs through binding and repositioning of the…
Heterotrimeric G proteins are composed of alpha, beta and gamma subunits. The alpha chain contains the guanine nucleotide-binding site. Interacts with RHO; interaction promotes GDP release and GTP binding (By similarity). Interacts with the PDE6 heterotetrameric complex; two GNAT1-GTP molecules bind both the catalytic core (PDE6A and PDE6B) and the inhibitory PDE6G subunits, inducing…
Photoreceptor outer segment membrane, Membrane, Photoreceptor inner segment
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3RBQ | X-ray | 2.0 Å | G/H/I/J/K/L=2-11 |
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