Guanine nucleotide-exchange factor SEC12 (SEC12) is a 471-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P11655.
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The mean pLDDT of this model is 85.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 74% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER. This function involves the cytoplasmic domain of the protein, which is thought to interact with the small GTP-binding protein SAR1. Required for autophagy
Endoplasmic reticulum membrane, Golgi apparatus, cis-Golgi network membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4H5I | X-ray | 1.36 Å | A/B=1-354 |
| 6X90 | X-ray | 2.26 Å | B=1-354 |
| 4H5J | X-ray | 2.6 Å | A/B=1-354 |
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