Coagulation factor V (F5) is a 2224-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P12259.
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The mean pLDDT of this model is 61.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 22% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 42% |
What pLDDT means and how to read it
Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin
Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain, non-covalently bound. The interaction between the two chains is calcium-dependent. Forms heterodimer with SERPINA5
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9I24 | X-ray | 1.2 Å | C=684-698 |
| 3P6Z | X-ray | 1.7 Å | C/I=685-737 |
| 3S9C | X-ray | 1.8 Å | B=1561-1574 |
| 1CZT | X-ray | 1.87 Å | A=2065-2224 |
| 1CZS | X-ray | 1.9 Å | A=2065-2224 |
| 1CZV | X-ray | 2.4 Å | A/B=2065-2224 |
| 3P70 | X-ray | 2.55 Å | M/N/O/P=685-737 |
| 9MOV | EM | 3.0 Å | A=29-737, B=1574-2224 |
| 8TN9 | EM | 3.05 Å | A=29-2224 |
| 9MOT | EM | 3.15 Å | A=29-737, B=1574-2224 |
| 8FDG | EM | 3.2 Å | A=29-2224 |
| 9I2H | EM | 3.28 Å | A=29-737, B=1574-2224 |
| 7KVE | EM | 3.3 Å | B=29-2224 |
| 7KVF | EM | 3.6 Å | B=29-2224 |
| 7TPP | EM | 4.1 Å | C=29-737, D=1574-2224 |
| 7KXY | EM | 4.4 Å | A=29-737, B=1574-2224 |
| 9CTH | EM | 6.47 Å | A=29-737, E=1574-2224 |
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