Coagulation factor VIII (F8) is a 2133-residue protein from Sus scrofa. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P12263.
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The mean pLDDT of this model is 63.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 41% |
What pLDDT means and how to read it
Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa
Interacts with vWF. vWF binding is essential for the stabilization of F8 in circulation (By similarity)
Secreted, extracellular space
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7S0P | X-ray | 1.3 Å | M=1974-2129 |
| 4MO3 | X-ray | 1.7 Å | M=1971-2129 |
| 6MF0 | X-ray | 3.2 Å | A/B=3-405, A/B=762-1820 |
| 8TY1 | EM | 3.46 Å | A=1-405, A=762-1820 |
| 7K66 | X-ray | 3.92 Å | A=1-405, A=1438-1820 |
| 7KBT | X-ray | 4.15 Å | A=1-405, A=762-1820 |
| 8G6I | EM | 4.23 Å | A=1-405, A=1438-1820 |
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