Islet amyloid polypeptide (Iapp) is a 93-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P12969.
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The mean pLDDT of this model is 69.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 44% |
| 50 to 70 | Low: treat with caution | 55% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (By similarity). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes (PubMed:35324283). Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (PubMed:35324283)
Can form homodimers (By similarity). Interacts with IDE and INS (By similarity). Interaction with INS inhibits homodimerization and fibril formation (By similarity)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7TYF | EM | 2.2 Å | P=38-74 |
| 7TZF | EM | 2.4 Å | P=38-74 |
| 7TYX | EM | 2.55 Å | P=38-74 |
| 7TYI | EM | 3.3 Å | P=38-74 |
| 7TYL | EM | 3.3 Å | P=38-74 |
| 2KJ7 | NMR | A=38-74 |
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