mRNA export factor ICP27 homolog (EJRF1) is a 417-residue protein from Saimiriine herpesvirus 2. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P13199.
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The mean pLDDT of this model is 73.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Probably acts as a viral splicing factor that regulates viral RNA splicing. Functions as a multifunctional regulator of the expression of viral lytic genes (By similarity). Early protein that promotes the accumulation and nuclear export of viral intronless RNA transcripts by interacting with mRNAs and cellular export proteins
Homodimer. Homodimerization is required for transactivation (By similarity). Interacts with host ALYREF and with mouse ALYREF2. Associates in a complex with RNA, and host export factors NXF1/TAP and ALYREF or ALYREF2; these interactions allow nuclear export of viral transcripts
Host cytoplasm, Host nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6HAT | X-ray | 1.86 Å | A/B=146-417 |
| 6HAU | X-ray | 1.86 Å | A/B=146-417 |
| 2YKA | NMR | B=103-120 |
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