Potassium channel toxin alpha-KTx 1.1 is a 59-residue protein from Leiurus hebraeus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13487.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 89.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 70% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
This toxin inhibits numerous potassium channels: shaker (Ki=227 nM), Kv1.2/KCNA2 (nanomolar range), Kv1.3/KCNA3 (nanomolar range), Kv1.5/KCNA5 (Kd>100 nM), Kv1.6/KCNA6 (Ki=22 nM), KCa1.1/KCNMA1 (IC(50)=5.9 nM). It blocks channel activity by a simple bimolecular inhibition process. It also shows a weak interaction with nicotinic acetylcholine receptors (nAChR), suggesting it may weakly inhibit it (PubMed:31276191). It also exhibits pH-specific antimicrobial activities against bacteria (B.subtilis, E.coli and S.aureus) and the fungus C.albicans (PubMed:15118082)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4JTA | X-ray | 2.5 Å | Y=23-59 |
| 4JTD | X-ray | 2.54 Å | Y=23-59 |
| 4JTC | X-ray | 2.56 Å | Y=23-59 |
| 1BAH | NMR | A=23-59 | |
| 1CMR | NMR | A=29-59 | |
| 2A9H | NMR | E=23-59 | |
| 2CRD | NMR | A=23-59 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.