Keratin, type I cytoskeletal 10 (KRT10) is a 584-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13645.
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The mean pLDDT of this model is 64.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 39% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 48% |
What pLDDT means and how to read it
Structural component of intermediate filaments in suprabasal keratinocytes of stratified epithelia. Forms heteropolymers primarily with the type II keratin KRT1, and also with KRT2, assembling into intermediate filament networks that support terminal differentiation, mechanical resilience, and epidermal barrier formation
Heterodimers composed of one type I and one type II keratins; forms parallel coiled-coil heterodimers (PubMed:24940650, PubMed:27595935). Heterodimers associate in an antiparallel manner to form heterotetramers, which further assemble into higher-order keratin intermediate filaments (PubMed:24940650, PubMed:27595935). Forms a heterodimer with KRT1 (PubMed:24940650, PubMed:27595935). The KRT10…
Secreted, extracellular space, Cell surface, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6UUI | X-ray | 2.07 Å | X=337-456 |
| 4F1Z | X-ray | 2.3 Å | Q=499-512 |
| 6E2J | X-ray | 2.39 Å | B=195-296 |
| 3ASW | X-ray | 2.6 Å | B=473-487 |
| 6EC0 | X-ray | 2.98 Å | B=195-296 |
| 4ZRY | X-ray | 3.3 Å | A=337-456 |
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