Keratin, type II cytoskeletal 5 (KRT5) is a 590-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13647.
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The mean pLDDT of this model is 65.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 45% |
What pLDDT means and how to read it
Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Forms heteropolymers with type I partners including KRT14 and KRT15, contributing to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to the basal layer of the epidermis (PubMed:1372711, PubMed:1694855). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity)
Heterodimers composed of type I and type II keratin; forms parallel coiled-coil heterodimers (PubMed:1694855, PubMed:22705788, PubMed:24940650, PubMed:31995743). Two heterodimers associate in an antiparallel manner to form heterotetramers, which further assemble into higher-order intermediate filaments (PubMed:1694855). Forms a heterodimer (via 2B domains) with KRT14 (via 2B domains)…
Cytoplasm
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