Major surface antigen p30 (SAG1) is a 336-residue protein from Toxoplasma gondii. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13664.
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The mean pLDDT of this model is 81.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 63% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
Mediates binding to host cells and is especially important for parasite attachment and fitness in IFN-gamma/IFNG-stimulated host cells (PubMed:15151144, PubMed:40607979). May regulate binding between human S100A6 and vimentin (VIM) for cytoskeleton organization during the early stages of invasion into host cells (PubMed:34950858). Promotes TNF secretion in host cells probably by enhancing binding between human VIM and PRKCQ and activating NF-kappa-B pathway (PubMed:34950858). Promotes viability of host cells to satisfy the survival needs of parasites through the interaction with human RACK1 (PubMed:38157925)
Monomer (PubMed:12091874). Forms homodimers (PubMed:12091874). Interacts with human lysine-rich coiled-coil protein 1 (KRCC1) (PubMed:29351065, PubMed:31165984). Interacts with human S100A6 (PubMed:34950858). Interacts with human RACK1; the interaction promotes viability of host cells (PubMed:38157925)
Parasitophorous vacuole
Compare the prediction with experimentally determined structures of the same protein:
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