Tissue factor (F3) is a 295-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13726.
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The mean pLDDT of this model is 84.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 68% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade
Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII
Membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6R2W | X-ray | 1.25 Å | T=33-242 |
| 4YLQ | X-ray | 1.4 Å | T=33-251 |
| 8QOD | X-ray | 1.57 Å | C=1-243 |
| 2HFT | X-ray | 1.69 Å | A=33-243 |
| 2C4F | X-ray | 1.72 Å | T=38-112, U=123-242 |
| 3TH2 | X-ray | 1.72 Å | T=38-242 |
| 2A2Q | X-ray | 1.8 Å | T=38-242 |
| 3TH4 | X-ray | 1.8 Å | T=38-242 |
| 4IBL | X-ray | 1.8 Å | T=33-251 |
| 1JPS | X-ray | 1.85 Å | T=33-251 |
| 2AER | X-ray | 1.87 Å | T=38-242 |
| 8QQ6 | X-ray | 1.87 Å | C=1-243 |
| 2FLB | X-ray | 1.95 Å | T=34-251 |
| 1DAN | X-ray | 2.0 Å | T=37-116, U=122-242 |
| 1Z6J | X-ray | 2.0 Å | T=33-243 |
| 2EC9 | X-ray | 2.0 Å | T=38-112, U=123-242 |
| 2FIR | X-ray | 2.0 Å | T=38-242 |
| 1O5D | X-ray | 2.05 Å | T=34-251 |
| 2PUQ | X-ray | 2.05 Å | T=38-241 |
| 1FAK | X-ray | 2.1 Å | T=37-242 |
Showing 20 of 54 experimental structures (best resolution first).
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