Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1) is a 1106-residue protein from Oryctolagus cuniculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13806.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 85.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 58% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (By similarity). Plays an important role in excitation-contraction coupling (By similarity)
Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio
Membrane, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6JPA | EM | 2.6 Å | F=29-1075 |
| 6JP8 | EM | 2.7 Å | F=29-1075 |
| 8E56 | EM | 2.8 Å | F=1-1106 |
| 8E57 | EM | 2.8 Å | F=1-1106 |
| 6JP5 | EM | 2.9 Å | F=1-1074 |
| 6JPB | EM | 2.9 Å | F=29-1075 |
| 7JPX | EM | 2.9 Å | F=1-1106 |
| 7JPK | EM | 3.0 Å | F=1-1106 |
| 8E58 | EM | 3.0 Å | F=1-1106 |
| 8FD7 | EM | 3.1 Å | D=1-1106 |
| 7JPW | EM | 3.2 Å | F=1-1106 |
| 8EOG | EM | 3.3 Å | D=29-1079 |
| 7JPL | EM | 3.4 Å | F=1-1106 |
| 7JPV | EM | 3.4 Å | F=1-1106 |
| 5GJV | EM | 3.6 Å | F=1-1106 |
| 5GJW | EM | 3.9 Å | F=1-1106 |
| 3JBR | EM | 4.2 Å | F=1-1106 |
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