5GJW: PDB entry 5GJW

Structure of the mammalian voltage-gated calcium channel Cav1.1 complex for ClassII map. Determined by electron microscopy at 3.9 Å resolution. Released 14 Sept 2016.

Method
Electron microscopy
Resolution
3.9 Å
Organism
Oryctolagus cuniculus
Chains
5
Atoms
21,561
Mol. weight
402.2 kDa
Ligands
NAG, CA
Released
14 Sept 2016

Explore 5GJW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5GJW contains 114 α-helices and 86 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 64 helices, 10 β-strands

ElementResiduesLengthSheet
α-helix41-488
α-helix53-6917
α-helix82-10726
α-helix116-13823
α-helix163-1653
α-helix167-1737
α-helix174-1785
α-helix182-19312
α-helix194-1963
α-helix200-21718
β-strand22711
β-strand22812
β-strand23411
β-strand25912
α-helix278-28912
α-helix295-30410
α-helix311-3188
α-helix323-34220
α-helix344-3474
α-helix349-37325
α-helix424-4285
α-helix432-4354
α-helix438-4469
α-helix459-48426
α-helix488-4914
α-helix495-51420
α-helix521-53010
α-helix531-5377
α-helix545-58036
α-helix601-61111
α-helix616-62712
α-helix634-6374
α-helix638-68447
α-helix789-7968
α-helix799-81719
α-helix827-85125
α-helix856-8583
α-helix862-88221
α-helix895-8984
α-helix899-90911
α-helix914-9185
α-helix919-95032
β-strand955-95733
β-strand972-97544
β-strand983-98644
β-strand990-99233
α-helix1000-101112
α-helix1016-10249
α-helix1039-10413
α-helix1042-107231
α-helix1075-10773
α-helix1084-109411
α-helix1106-111510
α-helix1121-113313
α-helix1144-117128
α-helix1177-11793
α-helix1181-120424
α-helix1231-12344
α-helix1237-12404
α-helix1241-12488
α-helix1251-126616
α-helix1268-128619
α-helix1309-132012
α-helix1325-13295
α-helix1357-137620
α-helix1378-138710
α-helix1397-140913
β-strand1416-141835
α-helix1420-14278
α-helix1443-14497
β-strand1460-146235
α-helix1463-147412
α-helix1482-149716
α-helix1504-151411
Chain B: 3 helices, 6 β-strands
ElementResiduesLengthSheet
α-helix84-9411
α-helix100-1012
β-strand103-10756
β-strand11117
β-strand12817
β-strand133-13866
β-strand144-14966
β-strand156-16056
α-helix162-17312
Chain C: 10 helices, 6 β-strands
ElementResiduesLengthSheet
β-strand268-27146
α-helix275-2762
β-strand277-28048
α-helix290-30415
β-strand309-31468
α-helix318-3203
α-helix344-35714
α-helix358-3603
β-strand363-36868
α-helix375-3773
β-strand385-38958
α-helix394-40310
α-helix406-4094
α-helix412-42413
β-strand432-43438
α-helix439-45719
Chain E: 5 helices, 5 β-strands
ElementResiduesLengthSheet
α-helix2-54
α-helix8-2821
β-strand33-3649
β-strand48-5039
β-strand56-5949
β-strand78-8149
α-helix106-12722
α-helix137-16327
β-strand175-17849
α-helix180-20324
Chain F: 32 helices, 59 β-strands
ElementResiduesLengthSheet
α-helix32-5322
α-helix56-638
β-strand73-74210
α-helix78-11134
β-strand152-153211
β-strand160-161211
β-strand169112
α-helix181-1877
α-helix192-20110
β-strand208-211412
β-strand217-219312
α-helix240-2423
α-helix244-2485
β-strand254-255213
β-strand258-259214
β-strand261115
α-helix264-2663
α-helix269-28113
α-helix282-2843
β-strand290113
β-strand293114
β-strand296115
β-strand300115
α-helix314-32411
α-helix336-34510
β-strand357-358213
β-strand359-362414
α-helix372-3787
β-strand385-388414
β-strand389-391316
α-helix399-4079
β-strand413-415316
α-helix421-4244
α-helix428-4314
α-helix434-4374
β-strand447-448212
β-strand452-453212
β-strand460-468912
β-strand488-495812
α-helix496-5005
β-strand513117
β-strand516118
β-strand517119
β-strand522120
β-strand523119
β-strand562120
α-helix563-5664
α-helix571-58010
β-strand587-595921
α-helix5961
β-strand601122
β-strand602-610921
β-strand612-613218
β-strand621-622218
β-strand625117
β-strand627121
β-strand632-633210
α-helix634-6363
α-helix643-6519
α-helix653-6553
β-strand661-664423
α-helix679-69315
α-helix704-71815
α-helix719-7235
β-strand734-739623
β-strand743-746423
α-helix765-7728
β-strand776124
β-strand779123
β-strand795-796223
β-strand799-800223
β-strand803125
β-strand810125
β-strand813-819723
α-helix821-83212
β-strand852-856526
β-strand861127
β-strand862-865426
β-strand877127
α-helix878-8803
α-helix883-8919
β-strand896-902722
β-strand906-907228
β-strand975-976228
β-strand979-985722
β-strand993-998626
β-strand1003-1010826
β-strand1014124
β-strand1017-1022626
β-strand1040122
α-helix1046-10494

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Voltage-dependent L-type calcium channel subunit alpha-1SAprotein1873Oryctolagus cuniculusP07293 (AlphaFold model)
Voltage-dependent L-type calcium channel subunit beta-1Bprotein106Oryctolagus cuniculusP19517 (AlphaFold model)
Voltage-dependent L-type calcium channel subunit beta-1Cprotein199Oryctolagus cuniculusP19517 (AlphaFold model)
Voltage-dependent calcium channel gamma-1 subunitEprotein222Oryctolagus cuniculusP19518 (AlphaFold model)
Voltage-dependent calcium channel subunit alpha-2/delta-1Fprotein1106Oryctolagus cuniculusP13806 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>5GJW_1 Voltage-dependent L-type calcium channel subunit alpha-1S (chains A)
MEPSSPQDEGLRKKQPKKPLPEVLPRPPRALFCLTLQNPLRKACISIVEWKPFETIILLT
IFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLTVFSIEAAMKIIAYGFLFHQDAYLRS
GWNVLDFIIVFLGVFTAILEQVNVIQSNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVP
SLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYYIGTDIVATVENE
KPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYW
VNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLE
EDLRGYMSWITQGEVMDVEDLREGKLSLEEGGSDTESLYEIEGLNKIIQFIRHWRQWNRV
FRWKCHDLVKSRVFYWLVILIVALNTLSIASEHHNQPLWLTHLQDIANRVLLSLFTIEML
LKMYGLGLRQYFMSIFNRFDCFVVCSGILELLLVESGAMTPLGISVLRCIRLLRLFKITK
YWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLGMQLFGGRYDFEDTEVRRSNFDNF
PQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLNVFLAIA
VDNLAEAESLTSAQKAKAEERKRRKMSRGLPDKTEEEKSVMAKKLEQKPKGEGIPTTAKL
KVDEFESNVNEVKDPYPSADFPGDDEEDEPEIPVSPRPRPLAELQLKEKAVPIPEASSFF
IFSPTNKVRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRAESVRNQILGYFDIAFT
SVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSTISVVKILRVLR
VLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFFSCNDL
SKMTEEECRGYYYVYKDGDPTQMELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLL
YRAIDSNEEDMGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCE
LDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYVVTSSYFEYLMFALIMLNTICLGMQHY
HQSEEMNHISDILNVAFTIIFTLEMILKLLAFKARGYFGDPWNVFDFLIVIGSIIDVILS
EIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTF
IKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCA
TGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLIINLFVAVI
MDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCP
HRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKR
TSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDTVQIQAGLR
TIEEEAAPEIRRTISGDLTAEEELERAMVEAAMEERIFRRTGGLFGQVDTFLERTNSLPP
VMANQRPLQFAEIEMEELESPVFLEDFPQDARTNPLARANTNNANANVAYGNSNHSNNQM
FSSVHCEREFPGEAETPAAGRGALSHSHRALGPHSKPCAGKLNGQLVQPGMPINQAPPAP
CQQPSTDPPERGQRRTSLTGSLQDEAPQRRSSEGSTPRRPAPATALLIQEALVRGGLDTL
AADAGFVTATSQALADACQMEPEEVEVAATELLKARESVQGMASVPGSLSRRSSLGSLDQ
VQGSQETLIPPRP
Sequence of entity 2 (B), FASTA
>5GJW_2 Voltage-dependent L-type calcium channel subunit beta-1 (chains B)
SLEVLFQGPHMALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVEGVAITF
EPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQ
Sequence of entity 3 (C), FASTA
>5GJW_3 Voltage-dependent L-type calcium channel subunit beta-1 (chains C)
VPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHLFDGRISITRVTADISLAKRS
VLNNPSKHIIIERSNTRSSLAEVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAP
IIVYIKITSPKVLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACE
HLAEYLEAYWKATHPPSST
Sequence of entity 4 (E), FASTA
>5GJW_4 Voltage-dependent calcium channel gamma-1 subunit (chains E)
MSPTEAPKVRVTLFCILVGIVLAMTAVVSDHWAVLSPHMENHNTTCEAAHFGLWRICTKR
IALGEDRSCGPITLPGEKNCSYFRHFNPGESSEIFEFTTQKEYSISAAAISVFSLGFLIM
GTICALMAFRKKRDYLLRPASMFYVFAGLCLFVSLEVMRQSVKRMIDSEDTVWIEYYYSW
SFACACAAFVLLFLGGISLLLFSLPRMPQNPWESCMDAEPEH
Sequence of entity 5 (F), FASTA
>5GJW_5 Voltage-dependent calcium channel subunit alpha-2/delta-1 (chains F)
MAAGRPLAWTLTLWQAWLILIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVHQLV
DIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFA
SNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIDDANFRRQVSYQHAAVHIPTDIYEGSTI
VLNELNWTSALDDVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDV
RRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNA
QDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKII
MLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGA
IRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTN
LKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPT
INLRKRRPNVQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDER
YIDKGNRTYTWTPVNGTDYSSLALVLPTYSFYYIKAKIEETITQARYSETLKPDNFEESG
YTFLAPRDYCSDLKPSDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQ
NYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTA
PYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGP
VCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKS
YDYQSVCEPGAAPKQGAGHRSAYVPSIADILQIGWWATAAAWSILQQFLLSLTFPRLLEA
ADMEDDDFTASMSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIM
VESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDCXGVSGL
NPSLWSIIGIQFVLLWLVSGSRHCLL

Ligands and cofactors

IDNameFormulaCopies
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O68
CACalcium ionCa3

Primary citation

Structure of the voltage-gated calcium channel Cav1.1 at 3.6 angstrom resolution. Wu, J.P., Yan, Z., Li, Z.Q. et al. Nature (2016) 537:191-196. DOI 10.1038/nature19321 · PubMed

Other PDB entries of the same protein (UniProt P07293 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 5GJW directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.