Glycogen [starch] synthase, muscle (GYS1) is a 737-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13807.
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The mean pLDDT of this model is 84.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 72% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 15% |
What pLDDT means and how to read it
Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan
Part of the GYS1-GYG1 complex, a heterooctamer composed of a tetramer of GYS1 and 2 dimers of GYG1, where each GYS1 protomer binds to one GYG1 subunit (via GYG1 C-terminus); the GYS1 tetramer may dissociate from GYG1 dimers to continue glycogen polymerization on its own
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7ZBN | EM | 2.62 Å | A/B/C/D=1-737 |
| 8Z0A | EM | 2.84 Å | A/B/C/D=1-737 |
| 7Q0B | EM | 3.0 Å | A/B/C/D=1-737 |
| 7Q13 | EM | 3.0 Å | A/B/C/D=1-737 |
| 8CVX | EM | 3.5 Å | A/B/C/D=1-634 |
| 8CVZ | EM | 3.52 Å | A/B/C/D=1-634 |
| 8CVY | EM | 3.6 Å | A/B/C/D=1-634 |
| 7Q12 | EM | 3.7 Å | A/B/C/D=1-737 |
| 7Q0S | EM | 4.0 Å | A/B/C/D=1-737 |
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