D(2) dopamine receptor (DRD2) is a 443-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P14416.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 72.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 38% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 26% |
What pLDDT means and how to read it
G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:21645528, PubMed:32103023, PubMed:32528175, PubMed:33353947, PubMed:33571431, PubMed:37221270, PubMed:39103320). Dopamine binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:32103023, PubMed:32528175, PubMed:33353947, PubMed:33571431, PubMed:37221270). Dopamine receptors can be classified in two categories: (1) DRD2 (together with DRD3 and DRD4) is a…
Interacts with GNAO1, GNB1 and GNG2; interaction with a heterotrimeric G protein complex is essential for receptor activity (PubMed:39103320). Interacts with G(i) proteins, GNAI1, GNAI2 and GNAI3 (By similarity). Interacts with GNAI2 isoform sGi2; the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation (PubMed:17550964).…
Postsynaptic cell membrane, Cell membrane, Golgi apparatus membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5AER | X-ray | 2.19 Å | B/C=430-443 |
| 9BS9 | EM | 2.28 Å | R=1-443 |
| 9BSB | EM | 2.32 Å | R=1-443 |
| 7JVR | EM | 2.8 Å | R=1-443 |
| 6CM4 | X-ray | 2.87 Å | A=35-222, A=363-443 |
| 8IRS | EM | 3.0 Å | R=1-443 |
| 6LUQ | X-ray | 3.1 Å | A=35-222, A=367-443 |
| 7DFP | X-ray | 3.1 Å | A=35-238, A=364-443 |
| 8TZQ | EM | 3.2 Å | R=1-443 |
| 8U02 | EM | 3.28 Å | R=1-443 |
| 6VMS | EM | 3.8 Å | R=29-443 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.