Genome polyprotein is a 458-residue protein from Foot-and-mouth disease virus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P15072.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 94.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 90% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Autocatalytically cleaves itself from the polyprotein at the L/VP0 junction. Also cleaves the host translation initiation factors EIF4G1 and EIF4G3, in order to shut off the capped cellular mRNA transcription. Plays a role in counteracting host innate antiviral response using diverse mechanisms. Possesses a deubiquitinase activity acting on both 'Lys-48' and 'Lys-63'-linked polyubiquitin chains. In turn, inhibits the ubiquitination and subsequent activation of key signaling molecules of type I IFN response such as host RIGI, TBK1, TRAF3 and TRAF6. Inhibits host NF-kappa-B activity by inducing a decrease in RELA mRNA levels. Cleaves a peptide bond in the C-terminus of host ISG15, resulting…
Interacts with host ISG15
Host nucleus, Host cytoplasm, Virion, Host endoplasmic reticulum membrane, Host cytoplasmic vesicle membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1EJO | X-ray | 2.3 Å | P=859-873 |
| 1FMD | X-ray | 3.5 Å | 2=287-504, 3=505-723 |
| 1QGC | EM | 30.0 Å | 2=287-504, 3=505-723 |
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