Insulin receptor (Insr) is a 1372-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P15208.
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The mean pLDDT of this model is 78.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin (PubMed:38061240). Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the…
Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with SORBS1 but dissociates from it following insulin…
Cell membrane, Recycling endosome membrane, Late endosome, Lysosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1LK2 | X-ray | 1.35 Å | P=423-430 |
| 7SL7 | EM | 3.1 Å | A/B=1-1372 |
| 7SL1 | EM | 3.4 Å | A/B=1-1372 |
| 7SL3 | EM | 3.4 Å | A/B=1-1372 |
| 7STH | EM | 3.5 Å | A/B=1-1372 |
| 8DTM | EM | 3.5 Å | A/B=28-1372 |
| 7SL2 | EM | 3.6 Å | A/B=1-1372 |
| 7SL6 | EM | 3.7 Å | A/B=1-1372 |
| 8EZ0 | EM | 3.7 Å | A/B=28-1372 |
| 7STK | EM | 4.0 Å | A/B=1-1372 |
| 7STJ | EM | 4.4 Å | A/B=1-1372 |
| 8EYX | EM | 4.5 Å | A/B=28-1372 |
| 7STI | EM | 4.9 Å | A/B=1-1372 |
| 8EYY | EM | 4.9 Å | A/B=28-1372 |
| 7SL4 | EM | 5.0 Å | A/B=1-1372 |
| 8DTL | EM | 5.4 Å | A/B=28-1372 |
| 9DNN | EM | 6.1 Å | A/B=1-1372 |
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