Prostatic acid phosphatase (ACP3) is a 386-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P15309.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 92.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 87% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins (PubMed:10506173, PubMed:15280042, PubMed:20498373, PubMed:9584846, PubMed:8132635). Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (PubMed:10506173, PubMed:15280042)
Homodimer; dimer formation is required for phosphatase activity
Secreted, Cell membrane, Lysosome membrane, Nucleus, Cytoplasm, cytosol
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3PPD | X-ray | 1.5 Å | A=260-265 |
| 9NMV | X-ray | 1.97 Å | C=112-120 |
| 9NMY | X-ray | 2.01 Å | C=112-120 |
| 9NMU | X-ray | 2.1 Å | C=112-120 |
| 9NMW | X-ray | 2.11 Å | C=112-120 |
| 9NMX | X-ray | 2.19 Å | C=112-120 |
| 1ND6 | X-ray | 2.4 Å | A/B/C/D=33-386 |
| 9YTD | EM | 2.5 Å | C=112-120 |
| 1ND5 | X-ray | 2.9 Å | A/B/C/D=33-386 |
| 2HPA | X-ray | 2.9 Å | A/B/C/D=33-374 |
| 8XJ4 | EM | 3.19 Å | A/B=31-377 |
| 1CVI | X-ray | 3.2 Å | A/B/C/D=33-374 |
| 2L3H | NMR | A=248-286 | |
| 2L77 | NMR | A=248-286 | |
| 2L79 | NMR | A=248-286 | |
| 2MG0 | NMR | A=262-270 | |
| 7ZZV | NMR | A=85-120 |
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