Cyclic AMP-dependent transcription factor ATF-2 (ATF2) is a 505-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P15336.
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The mean pLDDT of this model is 57.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 13% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 25% |
| Below 50 | Very low: often disordered regions | 50% |
What pLDDT means and how to read it
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response (PubMed:11932306, PubMed:15105425, PubMed:15916964, PubMed:22304920, PubMed:2529117). Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3') (PubMed:11932306, PubMed:2529117). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death (PubMed:22304920). In liver, acts as a…
Binds DNA as a dimer and can form a homodimer in the absence of DNA (PubMed:11932306, PubMed:2529117). Can form a heterodimer with JUN (PubMed:22275354). Heterodimerization is essential for its transcriptional activity (PubMed:22275354). Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity (PubMed:9748258). Interacts with the HK1/VDAC1 complex…
Nucleus, Cytoplasm, Mitochondrion outer membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6ZQS | X-ray | 1.95 Å | B=83-102 |
| 8YPE | X-ray | 1.95 Å | B=46-80 |
| 8YPF | X-ray | 2.0 Å | B=46-90 |
| 9Y0R | X-ray | 2.2 Å | B=352-378 |
| 6ZR5 | X-ray | 2.7 Å | C/D=20-58 |
| 1T2K | X-ray | 3.0 Å | D=354-414 |
| 4H36 | X-ray | 3.0 Å | B=48-55 |
| 1BHI | NMR | A=19-56 |
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