4H36: JNK3

Crystal Structure of JNK3 in Complex with ATF2 Peptide. Determined by X-ray diffraction at 3.0 Å resolution. Released 21 Nov 2012.

Method: X-ray diffraction
Resolution: 3.0 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,873
Mol. weight: 42.22 kDa
Released: 21 Nov 2012

Explore 4H36 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4H36 contains 21 α-helices and 11 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 21 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	48-53	6	1
β-strand	56-61	6	1
β-strand	64-72	9	2
β-strand	76-83	8	2
β-strand	88-95	8	2
α-helix	102-114	13
β-strand	123	1	3
β-strand	126-130	5	2
β-strand	143-147	5	2
β-strand	151-152	2	3
α-helix	153-157	5
α-helix	163-182	20
β-strand	195-197	3	3
β-strand	203-205	3	3
α-helix	216-219	4
α-helix	226-229	4
α-helix	232-235	4
α-helix	244-258	15
α-helix	268-279	12
α-helix	281-283	3
α-helix	284-287	4
α-helix	292-299	8
α-helix	304-308	5
α-helix	309-312	4
α-helix	327-339	13
α-helix	344-346	3
α-helix	348-349	2
α-helix	350-355	6
α-helix	357-360	4
α-helix	365-368	4
α-helix	378-380	3
α-helix	387-399	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Mitogen-activated protein kinase 10	A	protein	356	Homo sapiens	P53779 (AlphaFold model)
Cyclic AMP-dependent transcription factor ATF-2	B	protein	8	Homo sapiens	P15336 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4H36_1 Mitogen-activated protein kinase 10 (chains A)
DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH
AKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHE
RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV
VTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCP
EFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP
AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN

Sequence of entity 2 (B), FASTA

>4H36_2 Cyclic AMP-dependent transcription factor ATF-2 (chains B)
KHEMTLKF

Primary citation

Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases. Laughlin, J.D., Nwachukwu, J.C., Figuera-Losada, M. et al. Structure (2012) 20:2174-2184. DOI 10.1016/j.str.2012.09.021 · PubMed

Other PDB entries of the same protein (UniProt P53779 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3OY1 1.7 Å, Highly Selective c-Jun N-Terminal Kinase (JNK) 2 and 3 Inhibitors with In Vitro CNS-like…
7ORF 1.7 Å, Crystal structure of JNK3 in complex with FMU-001-367 (compound 1)
7KSI 1.73 Å, Thiophenyl-Pyrazolourea Derivatives as Potent, Brian Penetrant, Orally Bioavailable, and…
6EMH 1.76 Å, Crystal structure of JNK3 in complex with a pyridinylimidazole inhibitor
4WHZ 1.79 Å, Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies…
6EQ9 1.83 Å, Crystal structure of JNK3 in complex with AMP-PCP
7KSK 1.84 Å, Thiophenyl-Pyrazolourea Derivatives as Potent, Brian Penetrant, Orally Bioavailable, and…
8WGF 1.85 Å, The Crystal Structure of JNK3 from Biortus.
8BZP 1.86 Å, JNK3 (Mitogen-activated protein kinase 10) in Complex with Compound 23 bearing a…
2B1P 1.9 Å, inhibitor complex of JNK3
4W4W 1.9 Å, JNK2/3 in complex with N-(2-methylpyridin-4-yl)-3-{4-[(phenylcarbamoyl)amino]-1H-pyrazol-…
4X21 1.95 Å, The MAP kinase JNK3 as target for halogen bonding

Browse structure collections

About this viewer

MolViewer shows 4H36 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.