Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) is a 2171-residue protein from Oryctolagus cuniculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P15381.
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The mean pLDDT of this model is 64.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 10% |
| 70 to 90 | Confident: backbone generally right | 45% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 33% |
What pLDDT means and how to read it
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:15615847, PubMed:17525370, PubMed:21127204, PubMed:2169433, PubMed:22649239, PubMed:22928916, PubMed:23145875, PubMed:2474130, PubMed:29363593, PubMed:8232554, PubMed:9278523, PubMed:9502794). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (PubMed:23145875). Plays an important role in excitation-contraction coupling in the heart (PubMed:17525370, PubMed:22928916, PubMed:23145875). Required for normal heart development and normal regulation of heart rhythm (By similarity). Required for normal contraction of…
Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1C) and ancillary beta, gamma and delta subunits (PubMed:17525370, PubMed:21127204). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains only one of each type of subunit (Probable). CACNA1C channel activity is modulated by ancillary subunits, such as CACNB1,…
Cell membrane, Cell membrane, sarcolemma, Perikaryon, Postsynaptic density membrane, Cell projection, dendrite, Cell membrane, sarcolemma, T-tubule
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