6CTB: Apo-Calmodulin

Apo-Calmodulin Bound to Calcium Voltage Gated Channel 1.2 IQ-Motif. Determined by solution NMR. Released 25 Sept 2019.

Method: Solution NMR
Organisms: Xenopus laevis, Oryctolagus cuniculus
Chains: 2
Atoms: 757
Mol. weight: 19.77 kDa
Released: 25 Sept 2019

Explore 6CTB in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6CTB contains 5 α-helices and 2 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	87-91	5
β-strand	100-102	3	1
α-helix	103-110	8
α-helix	119-129	11
β-strand	136-138	3	1
α-helix	140-143	4

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	1647-1664	18

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin-1	A	protein	147	Xenopus laevis	P0DP33 (AlphaFold model)
Voltage-dependent L-type calcium channel subunit alpha-1C	B	protein	25	Oryctolagus cuniculus	P15381 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6CTB_1 Calmodulin-1 (chains A)
DQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNG
TIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEV
DEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B), FASTA

>6CTB_2 Voltage-dependent L-type calcium channel subunit alpha-1C (chains B)
TVGKFYATFLIQEYFRKFKKRKEQG

Primary citation

apo-Calmodulin Bound to Calcium Voltage Gated Channel 1.2 IQ-Motif. Turner, M.L., Anderson, D.E., Ames, J.B. To be published.

Other PDB entries of the same protein (UniProt P0DP33 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1IQ5 1.8 Å, Calmodulin/nematode CA2+/Calmodulin dependent kinase kinase fragment
2COL 2.2 Å, Crystal structure analysis of CyaA/C-Cam with Pyrophosphate
4R8G 3.5 Å, Crystal Structure of Myosin-1c tail in complex with Calmodulin
1Y0V 3.6 Å, Crystal structure of anthrax edema factor (EF) in complex with calmodulin and…
1CFC Calcium-free calmodulin
1CFD Calcium-free calmodulin
1CFF NMR solution structure of a complex of calmodulin with a binding peptide of the CA2+-pump
1CKK Calmodulin/rat CA2+/CALMODULIN dependent protein kinase fragment
1DMO Calmodulin, NMR, 30 structures
1F70 Refined solution structure of calmodulin N-terminal domain
1F71 Refined solution structure of calmodulin C-terminal domain
1MUX Solution NMR structure of calmodulin/w-7 complex: the basis of diversity in molecular…

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