Mucin-1 (MUC1) is a 1255-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P15941.
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The mean pLDDT of this model is 47.4 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 2% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 19% |
| Below 50 | Very low: often disordered regions | 71% |
What pLDDT means and how to read it
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack
The alpha subunit forms a tight, non-covalent heterodimeric complex with the proteolytically-released beta-subunit. Interaction, via the tandem repeat region, with domain 1 of ICAM1 is implicated in cell migration and metastases. Isoform 1 binds directly the SH2 domain of GRB2, and forms a MUC1/GRB2/SOS1 complex involved in RAS signaling. The cytoplasmic tail (MUC1CT) interacts with several…
Apical cell membrane, Secreted, Cell membrane, Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6BSC | X-ray | 1.3 Å | A=1041-1097, B=1098-1152 |
| 7V64 | X-ray | 1.56 Å | C=925-937 |
| 6BSB | X-ray | 1.6 Å | A=1041-1097, B=1098-1152 |
| 6FZQ | X-ray | 1.7 Å | P=921-926 |
| 8S6K | X-ray | 1.75 Å | M/N=927-933 |
| 6KX1 | X-ray | 1.77 Å | C=918-932 |
| 6FZR | X-ray | 1.8 Å | P=921-926 |
| 8AXH | X-ray | 1.85 Å | A=921-926 |
| 8S6T | X-ray | 1.85 Å | C=926-938 |
| 1SM3 | X-ray | 1.95 Å | P=919-931 |
| 8S6V | X-ray | 1.95 Å | M/N=927-935 |
| 5T6P | X-ray | 1.97 Å | E/F=921-928 |
| 6TGG | X-ray | 2.0 Å | P=921-926 |
| 7V4W | X-ray | 2.1 Å | C=925-937 |
| 5T78 | X-ray | 2.2 Å | E/F=921-928 |
| 7V7K | X-ray | 2.2 Å | C=925-937 |
| 7Q4I | X-ray | 2.4 Å | F/G=921-926 |
| 8P6I | X-ray | 2.5 Å | A/a=921-929 |
| 2FO4 | X-ray | 2.7 Å | P=920-927 |
| 7VAZ | X-ray | 2.73 Å | E/G/I=925-937 |
Showing 20 of 23 experimental structures (best resolution first).
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