Aggrecan core protein (ACAN) is a 2530-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P16112.
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The mean pLDDT of this model is 51.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 15% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 54% |
What pLDDT means and how to read it
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region
Forms a complex (via covalent bonds) with MATN1; the interaction increases with age of the organism via an increase in occupancy of MATN1 binding sites (By similarity). Interacts with FBLN1 (By similarity). Interacts with COMP (PubMed:17588949)
Secreted, extracellular space, extracellular matrix
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4MD4 | X-ray | 1.95 Å | C=89-103 |
| 9DFF | X-ray | 2.59 Å | A/B=21-351 |
| 7RDV | X-ray | 2.9 Å | H=91-101 |
| 9DFT | X-ray | 3.5 Å | A/B=21-351 |
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