Kinesin heavy chain (Khc) is a 975-residue protein from Drosophila melanogaster. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P17210.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 76.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 25% |
| 70 to 90 | Confident: backbone generally right | 51% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria
Oligomer composed of two heavy chains and two light chains
Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5JVU | X-ray | 1.95 Å | A/B=334-367 |
| 5JVR | X-ray | 2.1 Å | A/B/C/D/E/F/G/H=345-358 |
| 2Y65 | X-ray | 2.2 Å | A/B/C/D=1-365, W/X/Y=937-952 |
| 5JVS | X-ray | 2.25 Å | A=334-367 |
| 7BJS | X-ray | 2.28 Å | A/B=855-941 |
| 2Y5W | X-ray | 2.7 Å | A/B=1-365 |
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