Alpha-insect toxin LqhaIT is a 85-residue protein from Leiurus hebraeus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P17728.
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The mean pLDDT of this model is 92.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 75% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2YEO | X-ray | 1.08 Å | A=20-83 |
| 2ASC | X-ray | 1.1 Å | A=20-82 |
| 2ATB | X-ray | 1.6 Å | A/B=20-82 |
| 9LKZ | EM | 2.87 Å | C=20-85 |
| 8VQC | EM | 3.9 Å | H=20-82 |
| 1LQH | NMR | A=20-82 | |
| 1LQI | NMR | A=20-82 |
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