E3 ubiquitin-protein ligase ipaH7.8 (ipaH7.8) is a 565-residue protein from Shigella flexneri. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P18014.
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The mean pLDDT of this model is 84.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 45% |
| 70 to 90 | Confident: backbone generally right | 43% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
E3 ubiquitin ligase effector protein that interferes with host's innate immunity (PubMed:30872533, PubMed:34022140, PubMed:34492225, PubMed:36599845, PubMed:36991122, PubMed:36991125). Functions to alter host cell physiology and promote bacterial survival in host tissues (PubMed:30872533, PubMed:34022140, PubMed:34492225). Catalyzes ubiquitination of human gasdermins GSDMB and GSDMD, promoting their degradation by the proteasome, thereby preventing cell death (PubMed:34022140, PubMed:34492225, PubMed:36599845, PubMed:36991122, PubMed:36991125). In contrast, activates host cell pyroptosis in mouse cells: catalyzes ubiquitination of mouse Nlrp1b allele 1 protein, releasing the cleaved…
Secreted, Host cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3CKD | X-ray | 2.65 Å | A/B/C=255-560 |
| 7WJQ | X-ray | 2.7 Å | A=23-264 |
| 8GTJ | X-ray | 2.7 Å | B/D=23-262 |
| 8GTK | X-ray | 3.1 Å | B=23-262 |
| 8EFP | EM | 3.8 Å | B=1-565 |
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