Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) is a 435-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P18031.
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The mean pLDDT of this model is 81.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 67% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET
Interacts with EPHA3 (phosphorylated); dephosphorylates EPHA3 and may regulate its trafficking and function (PubMed:21135139). Interacts with MET (PubMed:18819921). Interacts with NCK1 (PubMed:21707536)
Endoplasmic reticulum membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7MN9 | X-ray | 1.24 Å | A=1-284 |
| 7MKZ | X-ray | 1.4 Å | A=1-301 |
| 9C66 | X-ray | 1.4 Å | B=304-313 |
| 8U1E | X-ray | 1.43 Å | A/B=1-321 |
| 8G65 | X-ray | 1.45 Å | A/B=1-298 |
| 7MNA | X-ray | 1.47 Å | A=1-284 |
| 7MOU | X-ray | 1.48 Å | A=1-284 |
| 2CM2 | X-ray | 1.5 Å | A=2-298 |
| 5QGF | X-ray | 1.51 Å | A=1-321 |
| 7GTW | X-ray | 1.51 Å | A=1-321 |
| 7GTX | X-ray | 1.51 Å | A=1-321 |
| 7GU5 | X-ray | 1.52 Å | A=1-321 |
| 7GU9 | X-ray | 1.53 Å | A=1-321 |
| 8G67 | X-ray | 1.53 Å | A/B=1-298 |
| 8G69 | X-ray | 1.53 Å | A/B=1-298 |
| 7GTY | X-ray | 1.54 Å | A=1-321 |
| 2F71 | X-ray | 1.55 Å | A=1-298 |
| 5QDK | X-ray | 1.55 Å | A=1-321 |
| 5QGB | X-ray | 1.55 Å | A=1-321 |
| 6XEA | X-ray | 1.55 Å | A=1-321 |
Showing 20 of 435 experimental structures (best resolution first).
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