Integrin beta-6 (ITGB6) is a 788-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P18564.
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The mean pLDDT of this model is 82.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 39% |
| 70 to 90 | Confident: backbone generally right | 45% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17158881, PubMed:17545607). It recognizes the sequence R-G-D in its ligands (PubMed:17158881, PubMed:17545607). Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17158881, PubMed:17545607). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation…
Heterodimer of an alpha and a beta subunit (PubMed:11807098, PubMed:17158881, PubMed:17545607). Interacts with FLNB (PubMed:11807098). Interacts with HAX1 (PubMed:17545607). ITGAV:ITGB6 interacts with FBN1 (PubMed:17158881). ITGAV:ITGB6 interacts with TGFB1 (PubMed:22278742, PubMed:28117447)
Cell membrane, Cell junction, focal adhesion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9CZD | X-ray | 2.23 Å | B=22-491 |
| 5FFG | X-ray | 2.25 Å | B=128-378 |
| 9CZA | X-ray | 2.49 Å | B=22-491 |
| 4UM9 | X-ray | 2.5 Å | B/D=18-491 |
| 9CZF | X-ray | 2.53 Å | B=22-491 |
| 9CZ7 | X-ray | 2.57 Å | B=22-491 |
| 4UM8 | X-ray | 2.85 Å | B/D=1-788 |
| 9XMM | EM | 2.88 Å | B=18-491 |
| 5NEM | EM | 3.1 Å | B=22-491 |
| 5NER | EM | 3.1 Å | B=22-491 |
| 5NET | EM | 3.1 Å | B=22-491 |
| 5NEU | EM | 3.1 Å | B=22-491 |
| 8TCG | EM | 3.4 Å | B=130-371 |
| 5FFO | X-ray | 3.49 Å | B/F=128-378 |
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