Lymphocyte activation gene 3 protein (LAG3) is a 525-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P18627.
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The mean pLDDT of this model is 78.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Inhibitory receptor on antigen activated T-cells (PubMed:20421648, PubMed:35761082, PubMed:7805750, PubMed:8647185). Delivers inhibitory signals upon binding to ligands, such as MHC class II, its main ligand present at the surface of antigen-presenting cells (APCs), and FGL1, which is secreted by hepatocytes and certain types of tumor cells (PubMed:30580966, PubMed:32920841, PubMed:35761082, PubMed:39671469, PubMed:7589152, PubMed:8647185, PubMed:9159144). Ligand-binding initiates a signaling that inhibits the T-cell receptor (TCR) in the immunological synapse, preventing T-cell activation (PubMed:40101708). Mechanistically, ligand-binding promotes (1) ubiquitination of the KIEELE motif,…
Homodimer; laterally engages two MHC class II molecules (PubMed:35761082, PubMed:39671469). Interacts with CD3E; disrupting the association between CD3E and LCK, thereby preventing TCR activation (PubMed:40592325)
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7UM3 | X-ray | 2.4 Å | A/B=82-97 |
| 7TZH | X-ray | 2.43 Å | B/D=261-450 |
| 9BF9 | X-ray | 3.4 Å | D=23-429 |
| 8SR0 | EM | 3.53 Å | D/X=1-525 |
| 8SO3 | EM | 3.61 Å | D/X=1-525 |
| 7TZG | X-ray | 3.71 Å | C/D=23-430 |
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