Regulator of chromosome condensation (RCC1) is a 421-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P18754.
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The mean pLDDT of this model is 93.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 91% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the…
Interacts with RAN (PubMed:11336674, PubMed:17435751, PubMed:18762580, PubMed:29040603). Interacts with KPNA3 (PubMed:34564892). Interacts (via N-terminus and RCC1 repeats) with KPNA4 (PubMed:29042532). Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation (PubMed:16820410)
Nucleus, Chromosome, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6DUB | X-ray | 1.2 Å | E/F=2-7 |
| 5E1D | X-ray | 1.45 Å | D/E=3-7 |
| 5E1B | X-ray | 1.65 Å | D/E=2-7 |
| 1A12 | X-ray | 1.7 Å | A/B/C=9-421 |
| 5E1M | X-ray | 1.75 Å | D/E=3-7 |
| 5E2A | X-ray | 1.75 Å | D/E=2-7 |
| 1I2M | X-ray | 1.76 Å | B/D=20-421 |
| 5E2B | X-ray | 1.95 Å | D/E=3-7 |
| 5E1O | X-ray | 2.0 Å | D/E=3-7 |
| 8UX1 | EM | 2.5 Å | L=2-421 |
| 5TBK | X-ray | 3.45 Å | I/J/K/L/M/N/O/P=1-421 |
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