5TBK: Human importin a3

Crystal structure of human importin a3 bound to RCC1. Determined by X-ray diffraction at 3.45 Å resolution. Released 13 Sept 2017.

Method

X-ray diffraction

Resolution

3.45 Å

Organism

Homo sapiens

Chains

16

Atoms

50,677

Mol. weight

823.73 kDa

Released

13 Sept 2017

Explore 5TBK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5TBK contains 329 α-helices and 249 β-strands across 16 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 33 helices, 0 β-strands

7 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

>5TBK_1 Importin subunit alpha-3 (chains A, B, C, D, E, F, G, H)
MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDS
DIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILV
HCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWA
LGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETI
QEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKV
QTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQ
VQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLL
TVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEI
IDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF

>5TBK_2 Regulator of chromosome condensation (chains I, J, K, L, M, N, O, P)
MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP
ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK
VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG
NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV
RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS
GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV
TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ
S

Primary citation

Three-dimensional context rather than NLS amino acid sequence determines importin alpha subtype specificity for RCC1. Sankhala, R.S., Lokareddy, R.K., Begum, S. et al. Nat Commun (2017) 8:979-979. DOI 10.1038/s41467-017-01057-7 · PubMed

Related structures

Other PDB entries of the same protein (UniProt O00629 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 6BW9 1.6 Å, Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 1
• 8HKW 1.9 Å, Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal
• 7LFC 2.1 Å, Structure of importin a3 bound to p50 NLS
• 7RG5 2.15 Å, Importin alpha3 in complex with p50 NLS
• 6BWA 2.2 Å, Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 2
• 6BVV 2.3 Å, Nipah virus W protein C-terminus in complex with Importin alpha 3
• 6BVZ 2.3 Å, Importin alpha 3 in cargo free state
• 6BWB 2.3 Å, Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 3
• 6WX8 2.3 Å, SOX2 bound to Importin-alpha 3
• 7RFY 2.5 Å, Importin alpha3 in complex with MERS ORF4B
• 7JJL 2.6 Å, Crystal structure of Importin Alpha 3 in complex with human LSD1 NLS
• 4UAE 2.7 Å, Importin alpha 3 delta IBB in complex with Influenza PB2 Nuclear Localization Domain

Browse structure collections

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