DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) is a 210-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P19388.
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The mean pLDDT of this model is 93.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 89% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template
Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively (PubMed:16809778, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:33674783, PubMed:34675218, PubMed:9852112). Pol I complex consists of a ten-subunit catalytic core composed of POLR1A/RPA1, POLR1B/RPA2,…
Nucleus, Nucleus, nucleolus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9EHZ | EM | 2.6 Å | E=1-210 |
| 7OB9 | EM | 2.7 Å | E=1-210 |
| 8XSO | EM | 2.7 Å | E=1-210 |
| 7AE1 | EM | 2.8 Å | E=1-210 |
| 9K39 | EM | 2.8 Å | E=1-210 |
| 7VBB | EM | 2.81 Å | E=1-210 |
| 7VBA | EM | 2.89 Å | E=1-210 |
| 7D58 | EM | 2.9 Å | E=1-210 |
| 9K36 | EM | 2.9 Å | E=1-210 |
| 9K2G | EM | 3.0 Å | E=1-210 |
| 9K3U | EM | 3.0 Å | E=1-210 |
| 7VBC | EM | 3.01 Å | E=1-210 |
| 7AE3 | EM | 3.1 Å | E=1-210 |
| 7D59 | EM | 3.1 Å | E=1-210 |
| 7OBA | EM | 3.1 Å | E=1-210 |
| 9K38 | EM | 3.1 Å | E=1-210 |
| 8XRM | EM | 3.13 Å | E=1-210 |
| 9EI1 | EM | 3.2 Å | E=1-210 |
| 9EI3 | EM | 3.2 Å | E=1-210 |
| 9FSO | EM | 3.28 Å | M=1-210 |
Showing 20 of 57 experimental structures (best resolution first).
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