TATA-box-binding protein (TBP) is a 339-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P20226.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 77.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:2194289, PubMed:2363050, PubMed:2374612, PubMed:27193682, PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27007846, PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C…
Binds DNA as monomer (PubMed:2194289, PubMed:2374612). Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27007846, PubMed:33795473, PubMed:9836642). Part of a TFIID-containing RNA polymerase II…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1CDW | X-ray | 1.9 Å | A=159-337 |
| 4ROC | X-ray | 1.9 Å | B=159-339 |
| 1NVP | X-ray | 2.1 Å | A=159-339 |
| 4ROE | X-ray | 2.2 Å | B=159-339 |
| 7NVU | EM | 2.5 Å | O=1-339 |
| 1JFI | X-ray | 2.62 Å | C=159-339 |
| 1C9B | X-ray | 2.65 Å | B/F/J/N/R=158-337 |
| 4ROD | X-ray | 2.7 Å | B=159-339 |
| 5N9G | X-ray | 2.7 Å | B/G=159-339 |
| 7NVS | EM | 2.8 Å | O=1-339 |
| 1TGH | X-ray | 2.9 Å | A=155-339 |
| 7NVT | EM | 2.9 Å | O=1-339 |
| 8S52 | EM | 2.9 Å | O=1-339 |
| 7ZWD | EM | 3.0 Å | O=1-339 |
| 7ZX8 | EM | 3.0 Å | O=1-339 |
| 9K3U | EM | 3.0 Å | U=1-339 |
| 8S51 | EM | 3.1 Å | O=1-339 |
| 7EGF | EM | 3.16 Å | P=1-339 |
| 7ZWC | EM | 3.2 Å | O=1-339 |
| 9FSO | EM | 3.28 Å | R=159-339 |
Showing 20 of 77 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.