8S51: DNA-directed RNA polymerase subunit

RNA polymerase II core initially transcribing complex with an ordered RNA of 8 nt. Determined by electron microscopy at 3.1 Å resolution. Released 17 Apr 2024.

Method: Electron microscopy
Resolution: 3.1 Å
Organisms: Sus scrofa, Homo sapiens, unidentified adenovirus
Chains: 23
Atoms: 44,796
Mol. weight: 920.92 kDa
Ligands: ZN, MG
Released: 17 Apr 2024

Explore 8S51 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8S51 contains 234 α-helices and 294 β-strands across 20 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 80 helices, 68 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15	1	1
β-strand	20-22	3	2
α-helix	25-27	3
α-helix	28-34	7
β-strand	43	1	3
β-strand	47	1	4
β-strand	52	1	4
α-helix	53	1
β-strand	56	1	3
β-strand	86-89	4	5
α-helix	97-99	3
α-helix	100-107	8
β-strand	110	1	6
β-strand	117	1	6
α-helix	124-132	9
α-helix	137-148	12
β-strand	153	1	7
β-strand	187	1	7
α-helix	188-189	2
β-strand	190-194	5	8
β-strand	197-201	5	8
β-strand	213-216	4	8
α-helix	218-226	9
α-helix	230-236	7
α-helix	245-248	4
β-strand	252-255	4	5
α-helix	256	1
α-helix	262-263	2
β-strand	264-265	2	9
β-strand	271-272	2	9
β-strand	274	1	10
α-helix	275-296	22
α-helix	300-318	19
β-strand	328-329	2	11
α-helix	334	1
β-strand	335	1	11
α-helix	336-337	2
α-helix	339-343	5
α-helix	349-353	5
β-strand	357-358	2	12
β-strand	362-369	8	13
β-strand	377-380	4	13
α-helix	382-387	6
β-strand	389-393	5	14
α-helix	396-398	3
α-helix	399-408	10
β-strand	416-420	5	14
β-strand	426-428	3	14
β-strand	445-449	5	14
α-helix	450	1
β-strand	455-459	5	13
β-strand	469-476	8	13
β-strand	482-484	3	13
α-helix	486-488	3
α-helix	489-492	4
β-strand	500-504	5	13
α-helix	509-518	10
β-strand	520	1	13
α-helix	522-524	3
β-strand	526	1	15
β-strand	533	1	15
α-helix	540-548	9
β-strand	554-555	2	16
α-helix	557-563	7
α-helix	564-566	3
α-helix	574	1
β-strand	575	1	17
α-helix	576-577	2
β-strand	579	1	18
β-strand	585	1	18
β-strand	586-587	2	16
α-helix	588-595	8
β-strand	602-605	4	19
α-helix	612-614	3
β-strand	627-631	5	19
β-strand	634-637	4	19
α-helix	642-645	4
α-helix	652-659	8
α-helix	662-683	22
β-strand	686	1	20
α-helix	689-691	3
α-helix	696-721	26
α-helix	725-728	4
α-helix	733-758	26
α-helix	765-768	4
α-helix	778-785	8
β-strand	789-790	2	21
α-helix	817-820	4
β-strand	822-823	2	21
α-helix	833-866	34
β-strand	872-873	2	22
β-strand	879-880	2	22
β-strand	886-888	3	22
α-helix	891-893	3
β-strand	896	1	23
α-helix	898-900	3
β-strand	902-905	4	24
α-helix	913-920	8
α-helix	927-933	7
β-strand	934	1	25
α-helix	936-944	9
α-helix	947-969	23
β-strand	976-979	4	24
α-helix	983-993	11
β-strand	1002	1	25
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1051-1053	3
α-helix	1054-1058	5
α-helix	1062-1078	17
β-strand	1080	1	23
α-helix	1081-1082	2
α-helix	1087-1096	10
α-helix	1097-1099	3
α-helix	1121-1129	9
β-strand	1139-1142	4	26
α-helix	1151-1161	11
β-strand	1164	1	27
β-strand	1170-1176	7	28
α-helix	1190-1196	7
α-helix	1201-1203	3
β-strand	1211-1216	6	28
α-helix	1218-1224	7
α-helix	1228-1238	11
α-helix	1240-1242	3
β-strand	1243-1247	5	28
β-strand	1256-1261	6	28
α-helix	1281-1292	12
β-strand	1299	1	27
β-strand	1306-1310	5	26
β-strand	1320-1322	3	29
β-strand	1328-1330	3	29
β-strand	1335-1339	5	26
α-helix	1343-1346	4
β-strand	1358-1359	2	26
α-helix	1362-1369	8
α-helix	1371-1386	16
α-helix	1395-1405	11
α-helix	1416-1419	4
α-helix	1426-1430	5
α-helix	1435-1445	11
β-strand	1448-1449	2	2
α-helix	1455-1459	5
α-helix	1467-1470	4
β-strand	1471-1475	5	30
α-helix	1477-1481	5

Chain B: 46 helices, 84 β-strands

Element	Residues	Length	Sheet
α-helix	19-21	3
α-helix	22-36	15
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
α-helix	63-64	2
β-strand	65-67	3	31
β-strand	83-94	12	31
β-strand	97-99	3	32
β-strand	105-107	3	32
α-helix	108-109	2
α-helix	110-115	6
β-strand	121-133	13	31
β-strand	141-153	13	31
α-helix	168-173	6
β-strand	185-187	3	33
β-strand	190-194	5	33
β-strand	196-200	5	34
β-strand	206-207	2	35
β-strand	215-216	2	36
β-strand	219-220	2	35
β-strand	223	1	37
β-strand	233	1	37
β-strand	237-240	4	36
β-strand	256-258	3	36
β-strand	263	1	38
β-strand	267-268	2	36
α-helix	269-275	7
α-helix	281-288	8
α-helix	296-300	5
α-helix	302-307	6
α-helix	314-323	10
β-strand	325	1	38
α-helix	332-344	13
α-helix	359-377	19
α-helix	388-390	3
β-strand	391-394	4	34
α-helix	396-424	29
α-helix	439-446	8
β-strand	453	1	39
β-strand	463	1	39
β-strand	467-469	3	33
α-helix	475-482	8
β-strand	484-486	3	34
β-strand	509	1	40
α-helix	517-519	3
β-strand	523-525	3	34
β-strand	526	1	40
β-strand	531-532	2	41
α-helix	539-547	9
α-helix	550	1
β-strand	551-552	2	42
β-strand	565-569	5	42
β-strand	572-577	6	42
α-helix	580-593	14
β-strand	602-606	5	42
β-strand	611-615	5	42
β-strand	621-627	7	41
β-strand	628-629	2	43
β-strand	632-633	2	43
α-helix	637-643	7
α-helix	653-658	6
β-strand	662-666	5	41
α-helix	669-671	3
β-strand	675-676	2	41
β-strand	695-696	2	41
α-helix	700-703	4
α-helix	714-716	3
β-strand	717	1	44
α-helix	719-728	10
β-strand	732	1	45
β-strand	747-751	5	46
β-strand	755	1	47
β-strand	759-760	2	48
β-strand	776-782	7	49
β-strand	783	1	20
β-strand	793-797	5	49
α-helix	798-801	4
β-strand	808-817	10	46
β-strand	827-829	3	50
β-strand	837	1	50
β-strand	848	1	51
β-strand	853	1	52
β-strand	854	1	51
α-helix	855	1
β-strand	859-860	2	46
β-strand	865	1	53
β-strand	867	1	52
β-strand	869-872	4	50
β-strand	889-891	3	50
β-strand	895	1	53
β-strand	902-911	10	46
β-strand	917-927	11	46
β-strand	934-937	4	49
β-strand	943-949	7	49
β-strand	956-957	2	54
β-strand	965-967	3	49
α-helix	969-971	3
β-strand	977	1	44
α-helix	978-993	16
β-strand	997-998	2	48
α-helix	1008-1015	8
α-helix	1016-1018	3
β-strand	1025-1026	2	49
β-strand	1028-1029	2	54
α-helix	1030	1
α-helix	1035	1
β-strand	1036	1	54
α-helix	1037	1
β-strand	1041-1050	10	49
β-strand	1051	1	45
α-helix	1055-1058	4
β-strand	1060-1062	3	13
β-strand	1067	1	55
β-strand	1074	1	55
α-helix	1078-1080	3
β-strand	1085-1086	2	12
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1113-1119	7	1
β-strand	1125	1	1
α-helix	1126	1
β-strand	1127-1129	3	56
β-strand	1134-1136	3	56
β-strand	1137	1	57
β-strand	1142	1	57
β-strand	1146-1152	7	1
α-helix	1153-1163	11
β-strand	1170-1172	3	2

Chain C: 10 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	58
β-strand	18-24	7	58
α-helix	28-40	13
β-strand	44-55	12	59
α-helix	61-69	9
β-strand	73	1	59
α-helix	83-84	2
α-helix	85-87	3
β-strand	99-106	8	59
α-helix	112	1
β-strand	113-115	3	60
α-helix	117-119	3
β-strand	121-122	2	59
β-strand	129	1	59
β-strand	151-153	3	60
β-strand	158-168	11	59
α-helix	174-176	3
β-strand	179	1	61
β-strand	184-186	3	58
α-helix	204-206	3
α-helix	218-220	3
β-strand	228-234	7	58
β-strand	235	1	61
α-helix	241-269	29

Chain D: 9 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	62
β-strand	21	1	62
α-helix	24-26	3
α-helix	34-49	16
α-helix	55-58	4
α-helix	59-70	12
α-helix	77-87	11
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-137	14

Chain E: 7 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	4-23	20
β-strand	26	1	63
α-helix	30-33	4
α-helix	37-43	7
β-strand	60-63	4	64
β-strand	64	1	63
β-strand	71-75	5	64
β-strand	82	1	65
α-helix	84-96	13
β-strand	102-106	5	64
β-strand	110	1	65
α-helix	112-118	7
β-strand	127-131	5	64
β-strand	147-150	4	66
α-helix	153-163	11
β-strand	172-173	2	66
α-helix	178-183	6
β-strand	190-197	8	66
β-strand	201-209	9	66

Chain F: 6 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	56	1	67
α-helix	57-58	2
α-helix	59-74	16
α-helix	77-79	3
α-helix	89-98	10
β-strand	104-109	6	30
β-strand	115-119	5	30
α-helix	120-122	3
β-strand	124	1	67
α-helix	125	1

Chain G: 3 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	2-13	12	30
α-helix	15-17	3
α-helix	23-34	12
β-strand	38-39	2	30
β-strand	43-54	12	30
β-strand	58-59	2	30
α-helix	60	1
β-strand	66-77	12	30
β-strand	84-92	9	68
β-strand	97-101	5	68
β-strand	104-108	5	68
β-strand	117-119	3	69
β-strand	127-130	4	69
β-strand	136-138	3	69
β-strand	142-153	12	68
β-strand	156-162	7	68
β-strand	169-170	2	68

Chain H: 2 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	4-14	11	70
β-strand	25-32	8	70
β-strand	38-44	7	70
β-strand	55-61	7	70
β-strand	65	1	71
β-strand	74	1	17
β-strand	83	1	71
α-helix	84-87	4
β-strand	90-91	2	70
β-strand	92	1	18
β-strand	94-101	8	70
β-strand	111-118	8	70
β-strand	121-128	8	70
α-helix	129-131	3
β-strand	139-148	10	70

12 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase subunit	A	protein	1970	Sus scrofa	A0A8D1DPV6
DNA-directed RNA polymerase subunit beta	B	protein	1300	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Sus scrofa	I3LCH3 (AlphaFold model)
RNA polymerase II subunit D	D	protein	184	Sus scrofa	A0A287ADR4 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	I3LSI7
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa	A0A4X1VYD0
DNA-directed RNA polymerase II subunit RPB11-a	K	protein	117	Sus scrofa	F1RKE4
RNA polymerase II subunit K	L	protein	58	Sus scrofa	A0A4X1TRS6

11 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>8S51_1 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Sequence of entity 2 (B), FASTA

>8S51_2 DNA-directed RNA polymerase subunit beta (chains B)
MKPLRPENPPKAELKGLLFVQQHCKTRLHSVAVTRPRGAATEESTPKLRMCSTNLSQALA
YFRAGANLTAASLWAGFRGSRRIFWERRKRKSLCLALRPGGACWRWLLAVSCVSLRGLGA
PGSCANMYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMS
VQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEAR
LRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCEL
NECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTST
IWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFED
PEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVS
DFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKE
VRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLT
FASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISV
GSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQM
DIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQ
DLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFP
DHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPA
GINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTR
ETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCST
FLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDM
PFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNL
LSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQP
MEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHT
YECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>8S51_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>8S51_4 RNA polymerase II subunit D (chains D)
MWGPAQPYSDSALSPKPRPFRAVFRGSALPFPAVRVEVRGRSMAAGGSDPRAGDVEEDAS
QLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRE
TIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKR
SFQY

Sequence of entity 5 (E), FASTA

>8S51_5 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>8S51_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 7 (G), FASTA

>8S51_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>8S51_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>8S51_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>8S51_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>8S51_11 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>8S51_12 RNA polymerase II subunit K (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	10
MG	Magnesium ion	Mg	1

Primary citation

Three-step mechanism of promoter escape by RNA polymerase II. Zhan, Y., Grabbe, F., Oberbeckmann, E. et al. Mol Cell (2024) 84:1699-1710.e6. DOI 10.1016/j.molcel.2024.03.016 · PubMed

Other PDB entries of the same protein (UniProt A0A8D1DPV6), best resolution first:

9HVQ 2.0 Å, Structure of the transcribing Pol II-DSIF-PAF-SPT6-RECQL5 complex
7NVU 2.5 Å, RNA polymerase II core pre-initiation complex with open promoter DNA
8QEP 2.5 Å, RNA polymerase II bound to Alu RNA right arm
8B3D 2.6 Å, Structure of the Pol II-TCR-ELOF1 complex.
7OOB 2.7 Å, Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2)
8UHG 2.7 Å, Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated
8UI0 2.7 Å, Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated
8WAV 2.72 Å, De novo transcribing complex 12 (TC12), the early elongation complex with Pol II…
8WAX 2.75 Å, De novo transcribing complex 14 (TC14), the early elongation complex with Pol II…
8WAZ 2.76 Å, De novo transcribing complex 16 (TC16), the early elongation complex with Pol II…
7F4G 2.78 Å, Structure of RPAP2-bound RNA polymerase II
8WAU 2.78 Å, De novo transcribing complex 11 (TC11), the early elongation complex with Pol II…

Browse structure collections

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