Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) is a 790-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P21580.
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The mean pLDDT of this model is 73.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 35% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with…
Homodimer. Interacts with TNIP1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF (By similarity). Interacts with YWHAZ and YWHAH. Interacts with IKBKG; the interaction is induced by TNF stimulation and by polyubiquitin. Interacts with RIPK1. Interacts with UBE2N; the…
Cytoplasm, Nucleus, Lysosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3VUX | X-ray | 1.7 Å | E/F/G=757-790 |
| 3ZJE | X-ray | 1.84 Å | A/B=1-366 |
| 3ZJD | X-ray | 1.87 Å | A/B=1-366 |
| 3ZJG | X-ray | 1.92 Å | A/B=1-366 |
| 3VUW | X-ray | 1.95 Å | E/F/G=757-789 |
| 3VUY | X-ray | 1.98 Å | D/E/F=757-790 |
| 3ZJF | X-ray | 2.2 Å | A/B=1-366 |
| 3DKB | X-ray | 2.5 Å | A/B/C/D/E/F=1-370 |
| 3OJ3 | X-ray | 2.5 Å | I/J/K/L/M/N/O/P=592-635 |
| 5V3P | X-ray | 2.5 Å | A/B/C/D/E/F=1-366 |
| 5LRX | X-ray | 2.85 Å | A/C/E/F=1-366 |
| 5V3B | X-ray | 3.0 Å | A/B/C/D/E/F=1-366 |
| 2VFJ | X-ray | 3.2 Å | A/B/C/D=1-366 |
| 3OJ4 | X-ray | 3.4 Å | C/F=592-635 |
| 2EQE | NMR | A=597-631 | |
| 2EQF | NMR | A=758-790 | |
| 2EQG | NMR | A=381-416 |
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