D(1A) dopamine receptor (DRD1) is a 446-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P21728.
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The mean pLDDT of this model is 72.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 41% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 27% |
What pLDDT means and how to read it
G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:11500503, PubMed:33571431, PubMed:33571432, PubMed:33750903, PubMed:34083522, PubMed:35676276, PubMed:35687690, PubMed:37221270). Dopamine binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:33571431, PubMed:33571432, PubMed:33750903, PubMed:34083522, PubMed:35676276, PubMed:35687690). Dopamine receptors can be classified in two categories: (1) DRD1…
Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DORIP1 (By similarity). Interacts with DRD2 (By similarity). Interacts with DRD3 (By similarity). Interacts with GHSR; forms a heteromer with GHSR in hippocampal neurons (By similarity)
Postsynaptic cell membrane, Cell projection, dendritic spine membrane, Cell projection, cilium membrane, Endoplasmic reticulum membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9LLJ | EM | 2.61 Å | R=2-446 |
| 9LLF | EM | 2.64 Å | R=2-446 |
| 9I54 | EM | 2.72 Å | R=1-446 |
| 9LLH | EM | 2.73 Å | R=2-446 |
| 9LLG | EM | 2.77 Å | R=2-220, R=235-270, R=276-446 |
| 9I52 | EM | 2.8 Å | R=1-446 |
| 7JVP | EM | 2.9 Å | R=1-446 |
| 9LLE | EM | 2.9 Å | R=2-446 |
| 9LWC | EM | 2.9 Å | R=1-446 |
| 7JV5 | EM | 3.0 Å | R=1-446 |
| 7JVQ | EM | 3.0 Å | R=1-446 |
| 7LJC | EM | 3.0 Å | R=1-446 |
| 7X2F | EM | 3.0 Å | F=1-446 |
| 8JXS | EM | 3.0 Å | A=11-362 |
| 9LLI | EM | 3.0 Å | R=2-220, R=276-446 |
| 7CKZ | EM | 3.1 Å | R=1-446 |
| 7F0T | EM | 3.1 Å | F=1-446 |
| 7F1O | EM | 3.13 Å | F=1-446 |
| 7CKY | EM | 3.2 Å | R=1-446 |
| 7LJD | EM | 3.2 Å | R=1-446 |
Showing 20 of 31 experimental structures (best resolution first).
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