C5a anaphylatoxin chemotactic receptor 1 (C5AR1) is a 350-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P21730.
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The mean pLDDT of this model is 85.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 67% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520, PubMed:1847994, PubMed:29300009, PubMed:36806352, PubMed:7622471, PubMed:8182049, PubMed:9553099). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:36806352, PubMed:37852260). C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed:36806352, PubMed:37852260).…
Homodimer (PubMed:29300009). May also form higher-order oligomers (PubMed:12835319). Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of the receptor and short-term desensitization to the ligand (PubMed:12464600, PubMed:37209686)
Cell membrane, Cytoplasmic vesicle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6C1R | X-ray | 2.2 Å | B=30-331 |
| 5O9H | X-ray | 2.7 Å | A/B=31-333 |
| 7Y67 | EM | 2.8 Å | D=1-330 |
| 6C1Q | X-ray | 2.9 Å | B=30-331 |
| 7Y64 | EM | 2.9 Å | D=1-330 |
| 7Y66 | EM | 2.9 Å | D=1-330 |
| 8HK5 | EM | 3.0 Å | A=1-350 |
| 9KUG | EM | 3.07 Å | A=2-350 |
| 9UMR | EM | 3.15 Å | D=2-350 |
| 7Y65 | EM | 3.2 Å | D=1-330 |
| 9UMX | EM | 3.2 Å | A=2-350 |
| 8IA2 | EM | 3.21 Å | A=2-350 |
| 8I0N | EM | 3.26 Å | U/V=334-342 |
| 8JZZ | EM | 3.31 Å | A=2-350 |
| 8GO8 | EM | 3.41 Å | U/V=331-350 |
| 8JZP | EM | 3.45 Å | A=2-350 |
| 8I0Z | EM | 4.33 Å | G/U/V=331-350 |
| 8GOO | EM | 4.4 Å | G/U/V=331-350 |
| 2K3U | NMR | B=7-28 |
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