Acetylcholinesterase (Ache) is a 614-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P21836.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 92.7 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 84% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft
Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen,…
Synapse, Secreted, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5DTI | X-ray | 2.0 Å | A/B=32-573 |
| 2HA2 | X-ray | 2.05 Å | A/B=32-574 |
| 4B82 | X-ray | 2.1 Å | A/B=32-574 |
| 4B85 | X-ray | 2.1 Å | A/B=32-574 |
| 5EIE | X-ray | 2.1 Å | A/B=32-574 |
| 8ORC | X-ray | 2.1 Å | A/B=32-574 |
| 2HA5 | X-ray | 2.15 Å | A/B=32-574 |
| 2WHQ | X-ray | 2.15 Å | A/B=32-576 |
| 1N5M | X-ray | 2.2 Å | A/B=32-572 |
| 2GYU | X-ray | 2.2 Å | A/B=32-574 |
| 2HA0 | X-ray | 2.2 Å | A/B=32-574 |
| 2WHP | X-ray | 2.2 Å | A/B=32-576 |
| 1N5R | X-ray | 2.25 Å | A/B=32-574 |
| 2HA3 | X-ray | 2.25 Å | A/B=32-574 |
| 2HA6 | X-ray | 2.25 Å | A/B=32-574 |
| 4ARB | X-ray | 2.25 Å | A/B=32-574 |
| 4B7Z | X-ray | 2.3 Å | A/B=32-576 |
| 7R02 | X-ray | 2.3 Å | A/B=32-574 |
| 7R2F | X-ray | 2.3 Å | A/B=32-574 |
| 9SNJ | X-ray | 2.3 Å | A/B=32-574 |
Showing 20 of 98 experimental structures (best resolution first).
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