Transcriptional regulatory protein SIN3 (SIN3) is a 1536-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P22579.
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The mean pLDDT of this model is 62.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 17% |
| 70 to 90 | Confident: backbone generally right | 33% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 39% |
What pLDDT means and how to read it
Catalytic component of the RPD3 histone deacetylase complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. SIN3 also has a RPD3 independent function required for normal longevity
Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6. Component of the RPD3C(S) complex composed of at least EAF3, RCO1, RPD3, SIN3, and UME1. Interacts with ESS1 and STB1
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6XAW | X-ray | 1.84 Å | A=402-473 |
| 6XDJ | X-ray | 2.2 Å | A/B/C/D=402-473 |
| 8HPO | EM | 2.6 Å | A/B=1-1536 |
| 8TOF | EM | 2.8 Å | A=1-1536 |
| 8KD3 | EM | 2.9 Å | B=2-1536 |
| 8KD5 | EM | 2.9 Å | B=2-1536 |
| 8KD4 | EM | 2.93 Å | B=215-1536 |
| 8HXX | EM | 3.0 Å | K=1-1536 |
| 8KD2 | EM | 3.02 Å | B=2-1536 |
| 8KD6 | EM | 3.07 Å | B=215-1536 |
| 8KD7 | EM | 3.09 Å | B=215-1536 |
| 8HXY | EM | 3.1 Å | K=1-1536 |
| 8HY0 | EM | 3.1 Å | K=1-1536 |
| 7YI0 | EM | 3.2 Å | A=1-1536 |
| 7YI3 | EM | 3.3 Å | A=1-1536 |
| 8W9C | EM | 3.3 Å | A=1-1536 |
| 8IHN | EM | 3.37 Å | K=1-1536 |
| 7YI2 | EM | 3.4 Å | A=1-1536 |
| 8KC7 | EM | 3.46 Å | B=215-1536 |
| 8GA8 | EM | 3.5 Å | A/D=1-1536 |
Showing 20 of 27 experimental structures (best resolution first).
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