Genome polyprotein is a 21-residue protein from Human rhinovirus 1A. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P23008.
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The mean pLDDT of this model is 72.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 91% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3 (By similarity). The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome (By similarity). Capsid protein VP1 mainly forms the vertices of the capsid (By similarity). Capsid protein VP1 interacts with host cell receptor to provide virion attachment to target host cells (By similarity). This attachment induces virion internalization (By similarity). Tyrosine kinases are probably involved in the entry process (By similarity). After binding to its receptor, the capsid undergoes conformational changes (By similarity). Capsid protein…
Interacts with capsid protein VP1 and capsid protein VP3 to form heterotrimeric protomers
Virion, Host cytoplasm, Host cytoplasmic vesicle membrane, Host nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1AYM | X-ray | 2.15 Å | 4=2-69 |
| 1AYN | X-ray | 2.9 Å | 4=2-69 |
| 1R1A | X-ray | 3.2 Å | 1=571-857, 2=70-332, 3=333-570, 4=2-45 |
| 2HWD | X-ray | 3.8 Å | 1=571-857, 2=70-332, 3=333-570, 4=2-45 |
| 2HWE | X-ray | 3.8 Å | 1=571-857, 2=70-332, 3=333-570, 4=2-45 |
| 2HWF | X-ray | 3.8 Å | 1=571-857, 2=70-332, 3=333-570, 4=2-45 |
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