Tyrosine-protein kinase JAK1 (JAK1) is a 1154-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P23458.
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The mean pLDDT of this model is 85.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Non-membrane spanning protein tyrosine kinase that phosphorylates signal-transducing subunits of cytokine receptor complexes like IL2RB, IL10RA, IFNAR2, IL6ST, LIFR, OSMR and IL31RA (PubMed:11909529, PubMed:12133952, PubMed:15194700, PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552, PubMed:9188471). Functionally, is involved in the IFN-alpha/beta/gamma signal pathway (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). Mechanistically, in response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly…
Interacts with IFNGR1 (PubMed:7615558). Interacts with JAKMIP1 (PubMed:15277531). Interacts with SHB (PubMed:12200137). Interacts (via N-terminus) with IL2RB and IL10RA (via its cytoplasmic domain) (PubMed:12133952). Interacts with FER (By similarity)
Endomembrane system
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6N7A | X-ray | 1.33 Å | A/B=854-1154 |
| 6N77 | X-ray | 1.64 Å | A/B=854-1154 |
| 6N7C | X-ray | 1.69 Å | A/B=854-1154 |
| 6GGH | X-ray | 1.7 Å | A/B=863-1154 |
| 6RSH | X-ray | 1.71 Å | A/B=854-1154 |
| 8S85 | X-ray | 1.75 Å | A/B=854-1154 |
| 6RSD | X-ray | 1.76 Å | A/B=854-1154 |
| 6N7D | X-ray | 1.78 Å | A=854-1154 |
| 4GS0 | X-ray | 1.8 Å | C=1033-1036 |
| 4L00 | X-ray | 1.8 Å | A/B=561-860 |
| 6ELR | X-ray | 1.8 Å | A/B=854-1154 |
| 6RSB | X-ray | 1.8 Å | A/B=854-1154 |
| 6RSE | X-ray | 1.8 Å | A/B=854-1154 |
| 6N7B | X-ray | 1.81 Å | A=854-1154 |
| 6AAH | X-ray | 1.83 Å | A/B=865-1154 |
| 6N78 | X-ray | 1.83 Å | A=854-1154 |
| 5WO4 | X-ray | 1.84 Å | A/B=854-1154 |
| 6RSC | X-ray | 1.85 Å | A/B=854-1154 |
| 6SM8 | X-ray | 1.85 Å | A/B=854-1154 |
| 4E5W | X-ray | 1.86 Å | A/B=854-1154 |
Showing 20 of 51 experimental structures (best resolution first).
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